Webinar – Development & Credibility Assessment of TAVI Heart-Valve FSI-Model

– For European prospects –
Join us for an insightful webinar where we delve into the latest advancements in Transcatheter Aortic Valve Implantation (TAVI) technology. TAVI heart valves have become a standard treatment, particularly for elderly patients, to improve blood flow by replacing a malfunctioning aortic valve. This minimally invasive procedure uses a catheter approach to place the device into the living heart.

Fluid-Structure Interaction (FSI) model

In this webinar, we will present the detailed Fluid-Structure Interaction (FSI) model of the Sapien-3 TAVI Heart Valve developed within the SimInSitu project. Our tiered modeling and Verification, Validation, and Uncertainty Quantification (VVUQ) approach enables the simulation of the in-vitro hemodynamic performance of the device.

Key Topics

– Device Components: Modeling of all relevant components, including the stent-frame, skirt, and three leaflets.
– Implantation Procedure: Simulation of the balloon inflation procedure.
– In-vitro Test Setup: Virtual placement of the heart-valve model into a simplified test setup.
– FSI Implementation: Use of Smoothed Particle Hydrodynamics (SPH) to simulate fluid-structure interaction.

Modeling Process Overview

We will discuss the first three levels of our modeling process:

For each level, we systematically conducted verification, validation, and uncertainty quantification activities, ensuring the credibility of our models.

Verification and Validation

The model has undergone extensive verification and validation using structural and hemodynamic test data from various publications. We conducted thorough uncertainty quantification and propagation for the structural and hemodynamic behavior using Monte Carlo simulations. Meta-modeling was partially necessary due to the complexity of the model.

Key Findings

– Stent Frame: Excellent agreement between experimental and simulation data for structural behavior.
– Leaflet Mechanics: Initial discrepancies were corrected by adjusting material properties and dimensions, resulting in improved structural and hemodynamic agreement.

Who should attend

This webinar is ideal for professionals and researchers in the field of cardiovascular devices, computational modeling, and simulation who are interested in the latest advancements in TAVI technology and simulation techniques.